Abstract
1. The histamine equivalent of the systemic blood is not significantly affected by the digestion of a meal. Whether histamine functions as a hormone in the second phase of gastric secretion has been neither proved nor disproved.2. The histamine equivalent of the gastric venous blood is unchanged by stimulation of the vagus effective in producing gastric secretion.3. The histamine equivalent of canine gastric juice, whether produced by vagal stimulation or by injection of histamine, is higher than that of blood plasma.4. The possibility is discussed that histamine mediates the secretory action of the vagus on the parietal cells.The author is greatly indebted to Dr. B. P. Babkin for much valuable advice and criticism.
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