Abstract
1. 1. An objective method for comparing the antihistaminic drugs in humans by use of the multiple scratch test is used to compare the antihistaminic properties of Pyribenzamine and Neohetramine; of Pyribenzamine and Thephorin; of Antistine, Neo-Antergan, and Pyribenzamine; and of Histadyl (01013), Benadryl, and Pyribenzamine. 2. 2. By the same technique, the ability of these drugs to alter the wheal produced by ragweed in sensitive patients is compared. 3. 3. The drugs can be arranged into three groups as far as their antihistaminic properties are concerned. Neo-Antergan, Histadyl (01013), Pyribenzamine, and Antistine are more effective in a significant proportion of cases than Benadryl, which is itself more effective than Neohetramine and Thephorin. 4. 4. Neo-Antergan, Histadyl (01013), Pyribenzamine, and Antistine are more effective than Thephorin (Nu 1504), Neohetramine, and Benadryl in altering the allergic wheal in humans. 5. 5. It is felt that the differences between the members of the group are not significant enough in this series to permit adequate rating, if indeed one is better than the other. It is probable that only when the stimulus is much stronger than that occurring naturally that any significant differences can be exhibited.
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