Abstract
This study determined quantitatively the sequential values for histamine and histaminase released into the blood of guinea pigs during anaphylactic shock. Mongrel male guinea pigs sensitized with crystalline egg albumin released histamine and histaminase into the blood within 15 to 30 seconds after the intravenous injection of the challenge dose of antigen. Values for histamine and histaminase in the blood increased rapidly within the first minute after the injection, with little increase from this time until the death of the animal in 5 to 6 minutes. Histaminase released by guinea pigs during anaphylactic shock is active at room temperature as well as at 37 °C. Data suggest that the histamine destruction is a first-order reaction. Histaminase is active in plasma as well as in whole blood. A small amount of histamine, presumably cell bound, is not destroyed by histaminase in whole blood. The concentration of histamine in plasma during anaphylactic shock is greater than that in whole blood. However, the values seem to parallel each other.
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