Abstract
MEASUREMENT of the concentrations of histamine in the plasma of rhesus (Macaca mulatto) and squirrel (Saimiri sciureus) monkeys after administration of the histamine-releasing agent, compound 48/80, or histamine has suggested that the rhesus monkey is more active in degrading histamine than the squirrel monkey1. Direct determination of histaminase activity in plasma showed that the rhesus monkey exhibits more activity of this enzyme than any other species tested, including man2. Squirrel monkeys and man were found to exhibit similar levels of this enzyme activity in the plasma2. In addition, squirrel monkeys, but not rhesus monkeys, responded to compound 48/80 by exhibiting an elevation of circulatory histamine1, as does man3.
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