Abstract
Plants have served for centuries as sources of compounds useful for human health such as antioxidant, anti-diabetic and antitumor agents. They are also rich in nutrients that improve the human diet. Growing demands for these compounds make it important to seek new sources for them. Hippophae rhamnoides L. is known as a plant with health-promoting properties. In this study we investigated the chemical composition and biological properties of bioactive components of ethanol extracts from leaves and twigs of H. rhamnoides L. Chemical components such as the total content of phenolic compounds, vitamins and amino acids and the antioxidant activities of these compounds in cellular and cell-free systems were assessed. The results suggest that the studied extracts are rich in bioactive compounds with potent antioxidant properties. Cytotoxicity and hemotoxicity assays showed that the extracts had low toxicity on human cells over the range of concentrations tested. Interaction with human serum albumin was investigated and conformational changes were observed. Our results indicate that leaf and twig extracts of H. rhamnoides L. should be considered as a non-toxic source of bioactive compounds which may be of interest to the food, pharmaceutical and cosmetic industries.
Highlights
Plants have served for centuries as sources of compounds useful for human health such as antioxidant, anti-diabetic and antitumor agents
When butanol extracts from H. rhamnoides leaves and twigs were investigated, the total phenolics content was higher than we found in ethanol ones (341.5 mg/g and 621.2 mg/g in leaf and twig extracts, respectively)[5,38]
In our study we examined the conformational changes in human serum albumin (HSA) upon titration with ethanol extracts using circular dichroism method
Summary
Plants have served for centuries as sources of compounds useful for human health such as antioxidant, anti-diabetic and antitumor agents. Hippophae rhamnoides L., commonly called sea buckthorn, belongs to the Elaeagnaceae family[1,2,3] It grows mainly in Europe and Asia, preferably in wet places, most often near rivers, as a shrub or low tree[1,4]. Flavonoids and phenolics (phenolic acids) are secondary metabolites formed in many plants that have high antioxidant activity and are known to protect cells against the injurious effects of free r adicals[14]. These compounds have been considered to be more. It has been suggested that, by acting as antioxidants, quercetin (the most abundant dietary flavonol), kaempferol, morin, myricetin, chlorogenic acid and rutin have anti-inflammatory, antiallergic, antiviral and anticancer effects and protect against liver and cardiovascular d iseases[18,19,20]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
