Abstract
Hippocampus, an area of cortex that plays an important role in thinking, planning and remembering. In Alzheimer’s disease (AD), the hippocampus is one of the first areas of the brain to become shriveled and this leads to the memory less, damage in learning and declaration of emotional behaviors. In this paper, we investigate the effects of sex on hippocampus gray matter (HGM) atrophy in four groups of participants, namely, males with AD (M-AD, n = 34), age-matched normal male controls (M-NC, n = 34), females with AD (F-AD, n = 34), and age matched normal female controls (F-NC, n = 34) from ADNI dataset. In this regard, Analysis of variance (ANOVA) is employed to compare means of HGM differences among groups. The statistical results obtained by ANOVA show that the distribution of HGM atrophy is effected by sex. Also there was a significant diagnosis with higher severity in the F-AD compared to M-AD. The AD studies based on the sex may help to figure out the root of AD mechanisms and poten-tially can be used as an imaging marker for the studies of AD in the future.
Highlights
In older adults, Alzheimer’s disease (AD), gradually destroys regions of the brain that are responsible for memory, learning, thinking, and behavior [1] [2]
We investigate the effects of sex on hippocampus gray matter (HGM) atrophy in four groups of participants, namely, males with AD (M-AD, n = 34), age-matched normal male controls (M-NC, n = 34), females with AD (F-AD, n = 34), and age matched normal female controls (F-NC, n = 34) from ADNI dataset
The aim of this study is to investigate hippocampus gray matter (HGM) atrophy in AD base on sex using structural MRI. sMRI is a powerful biomarker of the stage and intensity of the neurodegenerative aspect of AD pathology [10] [11]
Summary
Alzheimer’s disease (AD), gradually destroys regions of the brain that are responsible for memory, learning, thinking, and behavior [1] [2]. Investigators demonstrated a link between subjective memory lapses and lower hippocampal volume. Several studies have investigated the role of hippocampus in the AD [3]-[6]. Hippocampus volume change has huge potential as a marker at early stages of AD [7]. The aim of this study is to investigate hippocampus gray matter (HGM) atrophy in AD base on sex using structural MRI (sMRI). SMRI is a powerful biomarker of the stage and intensity of the neurodegenerative aspect of AD pathology [10] [11]
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