Abstract
IMPORTANCE: Hippocampal volume (HV) is a research marker of neurodegeneration and risk factor for memory decline due to Alzheimer's disease (AD) in cognitively normal (CN) elderly. Prior observational studies have suggested a number of factors influencing HV, including hypertension, obesity, and diabetes mellitus. However, few studies have assessed the impact that overall cardiovascular risk can have on HV in the setting of other AD biomarkers. QRISK2 is a cardiovascular risk calculator that can predict 10-year incidence of coronary heart disease, stroke, and transient ischemic attacks for individuals aged 25-84, and has been validated in large diverse population cohorts of over 2 million patients with annual updates to the calculator.
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