Abstract
The bipolar-schizophrenia network on intermediate-phenotypes (B-SNIP) consortium categorized individuals with psychosis into 3 biologically distinctive Biotypes based on cognition and EEG measures. Deficient verbal episodic memory (VEM) is strongly associated with poor clinical outcome. Hippocampal glutamatergic circuits support VEM, and glutamatergic mechanisms, implicated in cognitive and psychotic symptoms, are proposed as novel treatment targets.
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