Hippocampal evoked potentials to pitch deviances in an auditory oddball situation in the rabbit: no human mismatch-like dependence on standard stimuli

Abstract

Hippocampal auditory evoked potentials (AEP) were recorded in 10 rabbits when pitch deviant tones occurred in a series of standard tones (oddball situation). In control recordings, deviant tones were presented without intervening standard tones (deviant-alone situation). All AEP deflections observed in the oddball situation were found also in the deviant-alone situation. Thus, it appeared that none of the AEP deflections to deviant tones in the oddball situation was specific to a memory trace of preceding standard tones. This observation was in contradiction to such a specificity of the mismatch negativity (MMN) found in humans. Instead, a connection to a neuronal orienting reaction interpretation was shown to be apparent. A need for additional control procedures revealing a contribution of neural orienting responses in animal MMN experiments is discussed.