Abstract
Apparent diffusion coefficient (ADC) measurements were used to characterize hippocampal edema within 5 days of a prolonged febrile seizure (PFS) in a study at Great Ormond Street Hospital, London, UK.
Highlights
Apparent diffusion coefficient (ADC) measurements were used to characterize hippocampal edema within 5 days of a prolonged febrile seizure (PFS) in a study at Great Ormond Street Hospital, London, UK
A reduction in ADC between acute and 4-8 month follow-up measurements was indicative of early vasogenic edema, followed by recovery in children investigated within 2 days, but not in those measured between 3 and 5 days of a PFS
The authors propose that the ADC data reflect a preexisting developmental hippocampal abnormality that predisposes to a PFS
Summary
Apparent diffusion coefficient (ADC) measurements were used to characterize hippocampal edema within 5 days of a prolonged febrile seizure (PFS) in a study at Great Ormond Street Hospital, London, UK. A reduction in ADC between acute and 4-8 month follow-up measurements was indicative of early vasogenic edema, followed by recovery in children investigated within 2 days, but not in those measured between 3 and 5 days of a PFS. The findings are consistent with resolution of an early onset acute vasogenic edema that follows a PFS.
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