Abstract
The Hippo pathway is crucial in organ size control and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include the protein kinases of MST1/2, MAP4Ks, and LATS1/2 as well as the transcription co‐activators of YAP/TAZ and their DNA binding partners TEADs. The current paradigm for regulation of this pathway centers on phosphorylation‐dependent nuclear‐cytoplasmic shuttling of YAP/TAZ through a complex network of upstream components that act via the LATS1/2 kinases. We have found that the Hippo pathway is also regulated by cellular metabolism and energy status. There is a functional crosstalk between Hippo and mTOR pathways as YAP/TAZ induces expression of amino acid transporter to promote mTOR activity. YAP/TAZ activity is potently regulated by mechanical signals, such as matrix stiffness. We will discuss new mechanistic insights how the Hippo pathway is regulated by mechano signals.Support or Funding InformationCA196878GM51586This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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