Abstract
PathogenesisThere are multiple causes of hypopituitarism and they can be primary, due to pituitary involvement, or secondary, due to disorders of the hypothalamus or the pituitary stalk. Clinical manifestationsClinical manifestations are highly variable and they depend on the number of affected axis, the speed of onset and the age of the patient. DiagnosisEarly diagnosis and treatment is important because of its high morbidity and mortality. Hormone defficiency diagnosis is performed by measuring baseline level of hormones, except for ACTH and GH deficiencies that require dynamic tests. TreatmentTreatment of hypopituitarism is forever, with medical follow-up and hormone replacement therapy adjustment, according to clinical evaluation and baseline hormone levels, except for ACTH, which is mainly clinical monitoring.
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