Hiperglikemia dan Status Inflamasi pada Pasien Sindroma Koroner Akut

Abstract

ABSTRACTBackground: Hyperglycaemia in patients with acute coronary syndromes (ACS) is associated with increased cardiovas­cular (CV) risk. Hyperglycaemia in patients with ACS may be associated with increased systemic inflammation. Leukocytes are the major cellular mediators of inflammation and their elevated count is associated with higher CV event rate in ACS patients. Thus, it is possible that there is a relationship between hyperglycaemia and high leukocyte count among patients with ACS. Research Purpose: Aim of study is to investigate the relationship between hyperglycaemia and leukocyte count in ACS patients. Research Methods: This is a cross sectional study, which was held on January to April 2014 among 60 ACS patients in CVCU Wahidin Sudorohusodo Hospital. Glucose level and leukocyte count on admission were measured in 60 ACS patients. Patients was grouped into two groups, hyperglycemic ACS group (glycaemia on admission ≥ 140 mg/dL) and normoglycemic one (glycaemia on admission < 140mg/dL). Leukocyte count was compared to hyperglycemia and normoglycemia patients. Reseaerch Result: Mean of leucocytes count was significantly different between normoglycaemia and hyperglycaemia ACS patients, both in all patients (9.34 ± 2.58 x 103 vs 13.63 ± 3.10 x 103 , P<0.0001) and in non DM patients (9.34 ± 2.58 x 103 vs 14.08 ± 3.20 x 103 , P<0.0001). There was no significant difference of mean leucocytes count between DM and non DM ACS patients admitted with hyperglicaemia (12.38 ± 2.54 x 103 vs 14.08 ± 3.20 x 103 , P=0.121). Conclusion: The conclusion of this study was hyperglycaemia is assocciated with inflammatory status in ACS patients. Keywords :Acute coronary syndrome, hyperglycemia, and inflammation status