Hilfe für gestresste Hefen: der Zellwand-Integritätsweg

Abstract

The fungal cell wall gives shape and stability to cells and is a first barrier against adverse environmental conditions. It is a good target for antifungal drugs and important in biotechnology, life stock, and agriculture. The model yeast Saccharomyces cerevisiae is used to study cell wall synthesis, which is governed by the cell wall integrity (CWI) signal transduction pathway. Signalling is achieved through a conserved mitogen-activated protein kinase (MAPK) cascade whose human homologs are affected in various diseases.