Abstract
In this study, the high-throughput sequencing analysis of the transcriptome of hepatocellular carcinoma (HepG2) cells after 24 h of microcystin-LR (MC-LR)-treatment was performed to investigate the hepatotoxicity mechanism of MC-LR. The results showed that a total of 532 and 984 differentially expressed genes (DEGs) were found in cells after 0.5 and 50 μM of MC-LR-exposure, respectively, which was confirmed by the results of quantitative real-time PCR (qRT-PCR). Moreover, the functional analyzes of DEGs showed that MC-LR-exposure caused alterations in multiple signaling pathways, such as NF-κB, p53 and T-cell receptor pathways, which suggested that these pathways may be involved in MC-LR-hepatotoxicity and play an important role in human hepatitis and primary liver cancer caused by MC-LR.
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