Abstract

We report a new multi-parametric photoacoustic microscopy (PAM) system, which enables high-resolution imaging of blood perfusion, oxygenation and flow at 0.2-Hz frame rate over an area of 4.5×4.5 mm2. Extending the laser scanning range by using a cylindrically focused transducer (focus: 50 µm by 4.5 mm), it increases the speed of our previous hybrid-scan system with a weakly focused transducer (focal diameter: 250 µm) by 18-fold without compromising the sensitivity. We have demonstrated the feasibility of this technique in the transmission mode in vivo. Further development of a reflection-mode system will enable real-time cortex-wide imaging of cerebral hemodynamics and metabolism.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.