Abstract
High-speed capillary electrophoresis (HSCE) separations of pharmaceuticals are presented with high efficiency separations being achieved typically within 2 min. These results are obtained by applying high voltages across relatively short capillaries. Separation selectivity is shown to be similar to normal-speed CE. Quantitative HSCE impurity results compare well to those achieved by CE, TLC and HPLC. Analytical method validation criteria for HSCE such as linearity, precision and limits of detection are assessed.
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