Abstract
BackgroundAssociation of High-risk Human Papillomavirus (HR-HPV) with oral cancer has been established recently. Detecting these viruses in oral cavity is important to prevent oral lesions related to them. The purpose of this study was to evaluate the prevalence of HR-HPV in the oral cavity of women with cervical cancer, and their children. A total of 70 women, previously diagnosed with cervical cancer, and 46 children of these women, born by vaginal delivery only, were selected for this study. Buccal swabs were collected from their oral cavity and HPV detection was carried out using Hybrid Capture 2 high-risk HPV (HC2 HR-HPV) detection system. ResultsOut of 70 women with cervical cancer, four (5.71%) were found to be positive for HR-HPV in their oral cavity. No association of HR-HPV was found with sociodemographic profile, marital status, reproductive history, tobacco and alcohol usage, contraceptive pills usage, and presence of oral lesions (p>0.05). Among children, HR-HPV in the oral cavity was detected in only 1 of the 46 subjects examined (2.17%). Clinically healthy oral mucosa, without any oral lesions, was observed in all the HR-HPV positive subjects.ConclusionThe result of this study showed that there is low, if any, risk of HR-HPV infection in the oral cavity of women with cervical cancer. Further, our study suggests that there is very low risk for children of women with cervical cancer, to acquire and sustain HR-HPV in their oral cavity until childhood or adolescence.
Highlights
Association of High-risk Human Papillomavirus (HR-HPV) with oral cancer has been established recently
Considering the fact that almost all the cervical cancers are caused by HPV [22], this study was conducted to evaluate the prevalence of HRHPV in the oral cavity of women with cervical cancer, and their children
Our results showed the prevalence of HR-HPV in oral cavity of women with cervical cancer to be quite low, with only 4 out of 70 subjects (5.71%) testing positive for HR-HPV
Summary
Association of High-risk Human Papillomavirus (HR-HPV) with oral cancer has been established recently. Detecting these viruses in oral cavity is important to prevent oral lesions related to them. The purpose of this study was to evaluate the prevalence of HR-HPV in the oral cavity of women with cervical cancer, and their children. Human Papillomavirus (HPV) is an epitheliotropic, double stranded, circular DNA virus from Papovavirus family [1], which is found to infect cells in the basal layer of squamous epithelium [2]. HPV is classified as lowrisk and high-risk type, depending on its potential to cause malignant lesions such as cervical carcinomas [5]. In up to 92% of cervical malignancies, certain types of high-risk (HR) HPVs have been identified [6]. HR-HPV oncoproteins (E6 & E7) act by disrupting the function of tumor suppressor genes (pRb & p53), leading to excessive cell growth [1]
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