Abstract
We report a newly developed high speed 1050nm spectral domain optical coherence tomography (SD-OCT) system for imaging posterior segment of human eye. The system is capable of an axial resolution at ~10 µm in air, an imaging depth of 6.1 mm in air, a system sensitivity fall-off at ~6 dB/3mm and an imaging speed of 120,000 A-scans per second. We experimentally demonstrate the system’s capability to perform phase-resolved imaging of dynamic blood flow within retina, indicating high phase stability of the SDOCT system. Finally, we show an example that uses this newly developed system to image posterior segment of human eye with a large view of view (10 × 9 mm2), providing detailed visualization of microstructural features from anterior retina to posterior choroid. The demonstrated system parameters and imaging performances are comparable to those that a typical 1 µm swept source OCT would deliver for retinal imaging.
Highlights
Optical coherence tomography (OCT) [1,2] is a non-invasive, non-contact, high-resolution, high-sensitive and depth-resolved optical imaging modality, which has been widely applied in many biomedical imaging fields such as ophthalmology, dermatology, cardiology and embryology
We have demonstrated a newly developed high-speed 1050 nm spectral domain OCT (SD-OCT) system based on a new prototype high speed line-scan InGaAs camera
We have experimentally shown that this new system is capable of an axial resolution of 10 μm in air, an imaging range of 6.1 mm in air, a system sensitivity fall-off at 6 dB/3 mm, and an imaging speed of 120,000 A-lines per second
Summary
Optical coherence tomography (OCT) [1,2] is a non-invasive, non-contact, high-resolution, high-sensitive and depth-resolved optical imaging modality, which has been widely applied in many biomedical imaging fields such as ophthalmology, dermatology, cardiology and embryology. New development of SD-OCT system that is capable of providing comparable system performances to that of a typical SS-OCT system, such as longer imaging range (>5 mm), lower system sensitivity fall-off (~6dB/3mm), deeper penetration depth (using 1 μm wavelength), higher imaging speed (>100kHz A-line rate) and higher axial resolution in air (~10 μm), would be probably more appropriate for the generation ultrahigh speed OCT systems in ophthalmology. Received 1 Nov 2012; revised 9 Jan 2013; accepted 9 Jan 2013; published 16 Jan 2013 1 February 2013 / Vol 4, No 2 / BIOMEDICAL OPTICS EXPRESS 249 performances to that of a typical SSOCT system We describe this new SD-OCT system development along with experimental demonstrations of system performances, in terms of the imaging range, the system sensitivity fall-off and its phase stability to image dynamic retinal blood flow. We show the potential of the SD-OCT system to provide comprehensive assessment of both retina and choroid with a large field of view obtained from healthy volunteers
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