Abstract

The use of HPLC with continuous on-line post-elution photoirradiation followed by either diode-array UV or thermospray mass spectrometric detection is presented. These tandem techniques can greatly increase specificity of analysis, as demonstrated by select compounds whose UV or thermospray mass spectra are highly similar under lamp off conditions but significantly different after photoirradiation. The utility of the above approach for various compounds of forensic interest is presented.

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