Abstract
Methods developed for the separation of eburnane alkaloids have been applied for solving different analytical problems; plant extracts, mother liquors and pharmaceutical formulations have been analysed on both reversed-phase and silica packings. For the determination of apovincaminic acid ethyl ester (vinpocetine) in human blood plasma octylsilica was used as the stationary phase and acetonitrile–0.01 M aqueous ammonium carbonate as the eluent. For quantitation apovincamine can be used as an internal standard. The detection limit was found to be 2 ng/ml. To determine the corresponding acids of ester derivatives of eburnane alkaloids a reversed-phase ion-pair chromatographic method was developed.
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