Abstract
Liquid chromatography coupled with mass spectrometry and tandem mass spectrometry has been applied to investigate the in vivo metabolism of ginsenoside Rb 1 in rat. Both positive electrospray ionization mass spectrometry and negative electrospray ionization mass spectrometry were used to identify the Rb 1 and its metabolites in rat plasma, urine, and feces samples. Oxygenation and deglycosylation were found to be the major metabolic pathways of Rb 1 in rat. A total of nine metabolites were detected in urine and feces samples collected after intravenous and oral administration. Deglycosylated metabolism of Rb 1 generated other ginsenosides as the major metabolites, such as Rd, Rg 3 or F 2, Rh 2, or C-K. This result indicates that the ginsenoside Rb 1 has many pharmacological activities and could be used as a prodrug.
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