Abstract
Highly Virulent<i>Escherichia coli</i>O26, Scotland
Highlights
To the Editor: Hemolytic uremic syndrome (HUS) is a rare disorder characterized by microangiopathic hemolytic anemia, microthrombi, and multiorgan injury
In a recent study of pediatric HUS cases in Europe, children infected with E. coli O26 did not exhibit different clinical signs and symptoms from patients infected with other verotoxinproducing Escherichia coli (VTEC) serotypes [6]
To establish whether the host pathophysiologic responses to E. coli O157 and E. coli O26 strains differed, we analyzed a cohort of children with HUS who were infected with these VTEC serotypes
Summary
To the Editor: Hemolytic uremic syndrome (HUS) is a rare disorder characterized by microangiopathic hemolytic anemia, microthrombi, and multiorgan injury. Previous surveillance of childhood HUS in Scotland identified E. coli O157 in >90% of cases, non-O157 serotypes have been associated with HUS [5]. In 2010, several severe cases of HUS were reported to Health Protection Scotland by a consultant pediatric nephrologist.
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