Abstract
AbstractWe report here a new synthetic route to highly‐substituted tetraazamacrocycles. Raney nickel hydrogenation of macrocyclic phenylenediamine–acetylacetone condensation products gives cyclams in high yield with complexes all‐cis stereoselectivity. The extensive C‐substitution of the cyclam 2a changes its ligand properties markedly. The X‐ray structure analyses of NiII, CuII, and ZnII complexes of 2a reveals a deviation of the metal ion coordination geometry from the usual square‐planar arrangement. This may account for the differences in the redox properties of the NiII and CuII complexes of 2a leads to more positive oxidation and reduction potentials compared to the analogous unsubstituted cyclam complexes. While the binding constant between Zn(ClO4)2 and 2a is lower by a factor of 105 compared to cyclam, the subsequent binding of uridine to the zinc‐cyclam complexes in methanol/water is slightly stronger in the case of 2a · Zn(ClO4)2].
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
