Abstract
In this work, a double network bovine serum albumin-polyacrylamide (BSA-PAM) adhesive hydrogel was fabricated, in which combination of physical interactions including hydrogen bonds and chain entanglements, and chemical covalent photo-crosslinking. The BSA-PAM hydrogel exhibited excellent mechanical and adhesive properties. The composite hydrogel not only demonstrated excellent tensile properties (maximum force elongation 1552%~2037%), but also displayed extremely high fatigue resistance even when subjected to compress strains of up to 85%. More importantly, the BSA-PAM hydrogel showed excellent adhesiveness to various substrates (90 kPa~150 kPa for glass and 9.74 kPa~35.09 kPa for pigskin). This work provided a facile way of fabricating tough, stretchable and adhesive BSA-PAM hydrogels.
Highlights
Adhesive hydrogels were three-dimensional polymer networks that cross-linked either physically or chemically [1,2,3], which were used for tissue adhesion [4,5,6,7,8], hemostasis [9,10,11,12], and sealing against the leakage of air and body fluids during surgical procedures [13,14,15]
The bovine serum albumin-polyacrylamide (BSA-PAM) adhesive hydrogel was fabricated by a simple one-pot synthesis method (Scheme 1)
The double network bovine serum albumin (BSA)-PAM adhesive hydrogel was formed after UV irradiation (365 nm, 30 mW cm-2)
Summary
Adhesive hydrogels were three-dimensional polymer networks that cross-linked either physically or chemically [1,2,3], which were used for tissue adhesion [4,5,6,7,8], hemostasis [9,10,11,12], and sealing against the leakage of air and body fluids during surgical procedures [13,14,15]. A series of studies were carried out to evaluate the mechanical, adhesive, swelling and rheological properties of BSA-PAM hydrogels. The lap shear strength property of BSA-PAM adhesive hydrogels was tested as previously described [40, 41].
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