Highly stereoselective approach to chiral building block possessing three contiguous asymmetric centers. Preparation of four possible diastereomers of β,β′-dimethyl-bis-homoallylic alcohol derivative

Abstract

All four diastereomere of chiral alcohol 2 with three contiguous chiral centers were stereoselectively prepared via diastereoselective addition of nucleophiles (crotyl metal or H -) to α-methyl-β,γ-unsaturated carbonyl compounds 1 .