Abstract
Based on gold core and silver shell (Au@Ag NPs) substrate, a new surface enhanced Raman spectroscopy (SERS) method for detecting amprolium HCl was established. The drug molecules were immobilized between the gold core and the silver shell, which produced a sharp Raman signal enhancement. The value of enhancement factor (EF) was 1.60 × 107. The interaction between amprolium HCl and Au@Ag NPs were characterized by FT-IR and UV–vis. The effects of the amounts of HCl and NaCl, Au@Ag NPs and mixing time on the determination were studied and optimized by response surface analysis. Under the optimal conditions, there was a good linear relationship (r2 = 0.9949) between the concentration of amprolium HCl (6.6 × 10−10–2.0 × 10−7 mol L−1) and the intensity of SERS. The LOD was 0.48 nmol L−1. The influences of interfering substances were discussed in detail. The method was successfully used to detect amprolium HCl in the samples of chicken and duck, the recovery was 97.4%–103.5% with RSD 1.08%–3.39%.
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