Abstract
Polydiacetylenes are prepared from amphiphilic diacetylenes first through self-assembly and then polymerization. Different from common supramolecular assemblies, polydiacetylenes have stable structure and very special optical properties such as absorption, fluorescence, and Raman. The hydrophilic head of PDAs is easy to be chemically modified with functional groups for detection and imaging applications. PDAs will undergo a specific color change from blue to red, fluorescence enhancement and Raman spectrum changes in the presence of receptor ligands. These properties allow PDA-based sensors to have high sensitivity and specificity during analysis. Therefore, the PDAs have been widely used for detection of viruses, bacteria, proteins, antibiotics, hormones, sialic acid, metal ions and as probes for bioimaging in recent years. In this review, the preparation, polymerization, and detection mechanisms of PDAs are discussed, and some representative research advances in the field of bio-detection and bioimaging are highlighted.
Highlights
Biomolecule self-assembling is highly implicated in various biologic events through a variety of non-covalent interactions, such as hydrophobic interaction, hydrogen bonds, electrostatic interaction, and metal coordination (Bera et al, 2020; Yu et al, 2020)
Diacetylene amphiphile is generally composed of a hydrophilic head and a hydrophobic tail
We summarized the progress of PDA in the field of biological detection and bioimaging
Summary
Reviewed by: Yevgen Karpichev, Tallinn University of Technology, Estonia Xiaodong Zhuang, Shanghai Jiao Tong University, China. Sensitive Polydiacetylene Ensembles for Biosensing and Bioimaging. Polydiacetylenes are prepared from amphiphilic diacetylenes first through self-assembly and polymerization. Different from common supramolecular assemblies, polydiacetylenes have stable structure and very special optical properties such as absorption, fluorescence, and Raman. PDAs will undergo a specific color change from blue to red, fluorescence enhancement and Raman spectrum changes in the presence of receptor ligands. These properties allow PDA-based sensors to have high sensitivity and specificity during analysis. The preparation, polymerization, and detection mechanisms of PDAs are discussed, and some representative research advances in the field of bio-detection and bioimaging are highlighted
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