Abstract
The detection of small molecules has increasingly attracted the attention of researchers because of its important physiological function. In this manuscript, we propose a novel optical sensor which uses an optofluidic microbubble resonator (OFMBR) for the highly sensitive detection of small molecules. This paper demonstrates the binding of the small molecule biotin to surface-immobilized streptavidin with a detection limit reduced to 0.41 pM. Furthermore, binding specificity of four additional small molecules to surface-immobilized streptavidin is shown. A label-free OFMBR-based optical sensor has great potential in small molecule detection and drug screening because of its high sensitivity, low detection limit, and minimal sample consumption.
Highlights
Methods to detect small molecular analytes (
Various label-free optical techniques, such as surface plasmon resonance (SPR) [8], resonant waveguide grating (RWG) [9], resonant mirror (RM) [10,11], and high-Q optical microcavities [12,13,14,15,16] have been developed, but their sensitivities diminish with the size of the molecule, making it extremely challenging to detect small molecules
An optofluidic microbubble resonator (OFMBR) sensor consists of a microbubble coupled with a fiber taper
Summary
Methods to detect small molecular analytes (
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