Abstract
A zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT)-based glucose biosensor was fabricated via encapsulating glucose oxidase (GOx) in a one-step electropolymerization method. Integrating conductivity and hydrophilic properties, PSBEDOT provides a great framework for GOx immobilization and stabilization. The anti-fouling, high-sensitivity, and long-term stability properties of PSBEDOT-GOx make it a promising platform for long-term and continuous glucose monitoring.
Highlights
Haiyan Wu, a Chen-Jung Lee,a Huifeng Wang,b Yang Hu,b Megan Young,b Yu Han,c Fu-Jian Xu, d Hongbo Cong *a and Gang Cheng *b
The PCBMAbased glucose sensor shows great improvement as a blood glucose monitor, it is still limited by several issues: (1) most current zwitterionic materials only offer good biocompatibility for the biosensor, but compromise the electrochemical properties of the conductive substrate due to the non-conductive polymer backbone;[33,34,35] (2) the fabrication of the biosensor is complicated and time consuming since the conductive component generally needs to mix or covalently bind with the biocompatible but non-conductive moieties
The surface morphology and roughness, protein adsorption, response time, chronoamperometry properties, and stability in dry conditions, phosphate-buffered saline (PBS), and human blood plasma of the PSBEDOT glucose biosensor were systematically investigated in this work
Summary
Haiyan Wu, a Chen-Jung Lee,a Huifeng Wang,b Yang Hu,b Megan Young,b Yu Han,c Fu-Jian Xu, d Hongbo Cong *a and Gang Cheng *b. The most common and challenging problems for current enzymatic glucose biosensors are the insufficient long-term stability attributed to the intrinsic nature of the enzyme and relatively low sensitivity in complex biological uids, such as human blood, due to the non-speci c protein adsorption and cell attachment, originating from the hydrophobic or charged surface of conventional conducting polymers.
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