Highly sensitive and selective spectrofluorimetric determination of metoclopramide hydrochloride in pharmaceutical tablets and serum samples using Eu 3+ ion doped in sol–gel matrix

Abstract

A simple, sensitive and selective spectrofluorimetric method for the determination of Metoclopramide hydrochloride (MCP) is developed. The MCP can remarkably enhances the luminescence intensity of the Eu 3+ ion doped in sol–gel matrix at λ ex = 380 nm in DMSO at pH 8.7. The intensity of the emission band of Eu 3+ ion doped in sol–gel matrix increases due to energy transfer from MCP to Eu 3+ in the excited state. The enhancement of the emission band of Eu 3+ ion doped in sol–gel matrix at 617 nm was found to be directly proportional to the concentration of MCP with a dynamic range of 5 × 10 −9 − 1.0 × 10 −6 mol L −1 and detection limit of 2.2 × 10 −11 mol L −1.