Abstract
We report a breath hydrogen analyzer based on Pd-coated SnO2 nanorods (Pd-SnO2 NRs) sensor integrated into a miniaturized gas chromatography (GC) column. The device can measure a wide range of hydrogen (1–100 ppm), within 100 s, using a small volume of human breath (1 mL) without pre-concentration. Especially, the mini-GC integrated with Pd-SnO2 NRs can detect 1 ppm of H2, as a lower detection limit, at a low operating temperature of 152 °C. Furthermore, when the breath hydrogen analyzer was exposed to a mixture of interfering gases, such as carbon dioxide, nitrogen, methane, and acetone, it was found to be capable of selectively detecting only H2. We found that the Pd-SnO2 NRs were superior to other semiconducting metal oxides that lack selectivity in H2 detection. Our study reveals that the Pd-SnO2 NRs integrated into the mini-GC device can be utilized in breath hydrogen analyzers to rapidly and accurately detect hydrogen due to its high selectivity and sensitivity.
Highlights
We investigated the sensing performance of Pd-coated SnO2 nanorod arrays (NRs) integrated with a miniaturized gas chromatography (GC) column to detect H2 selectively for an application of a breath hydrogen analyzer
We found that the Pd-SnO2 NRs integrated with miniaturized gas chromatography (mini-GC) was capable of detecting 1 ppm of H2, as indicated in the inset of Figure 4b
We studied the sensing performance of a breath hydrogen analyzer based on a Pdcoated SnO2 nanorods (Pd-SnO2 NRs) integrated with miniaturized gas chromatography (GC) column
Summary
When the breath hydrogen analyzer was exposed to a mixture of interfering gases, such as carbon dioxide, nitrogen, methane, and acetone, it was found to be capable of selectively detecting only H2. Our study reveals that the Pd-SnO2 NRs integrated into the mini-GC device can be utilized in breath hydrogen analyzers to rapidly and accurately detect hydrogen due to its high selectivity and sensitivity. It is known that the gastrointestinal tract produces various gases, such as hydrogen, carbon dioxide, methane, and hydrogen sulfide, as the products of intestinal microbial metabolism, colonization, and subsequent fermentation [12]. The source of H2 in the breath can be from the bacterial fermentation of carbohydrates in the bowel caused by gastrointestinal diseases. Some symptoms of irritable bowel syndrome (IBS) can be described by SIBO, and it can be diagnosed by the hydrogen breath test.
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