Highly sensitive and novel dual-emission fluorescence nanosensor utilizing hybrid carbon dots-quantum dots for ratiometric determination of chlorpromazine.

Abstract

Herein, a ratiometric fluorimetric nanosensor is introduced for the sensitive and selective analysis of chlorpromazine (CPZ) via employing blue-emitting B-doped carbon dots (B-CDs) as the reference fluorophore and green-emitting CdTe capped thioglycolic acid (TGA) quantum dots (TGA-CdTe-QDs) as the specific recognition probe. The sensor exhibits dual emission centered at 440 and 560nm, under a single excitation wavelength of 340nm. Upon the addition of ultra-trace amount of CPZ, the fluorescence signal of TGA-CdTe-QDs declines due to electron transfer process from excited TGA-CdTe-QDs to CPZ molecules, whereas the fluorescence peak of B-CDs is unaffected. Therefore, a new fluorimetric platform was prepared for the assay of CPZ in the range of 2.2 × 10-10 to 5.0 × 10-9M with a detection limit of 1.3 × 10-10M. Moreover, the practicability of the designed strategy was investigated for the detection of CPZ in biological samples and the results demonstrate that it possesses considerable potential to be utilized in practical applications.