Abstract
Metallic nanoparticles are usually applied in biosensors as catalysts and/or mediators of electron transfer. We describe the development of amperometric biosensors (ABSs) based on oxidases and nanoparticles of CuCe (nCuCe). nCuCe, being an electro-active mediator and active peroxidase (PO) mimetic, was used as an H2O2-sensing platform in oxidase-based ABSs. ABSs for glucose, primary alcohols, methyl amine, catechol, and L-arginine, which are based on corresponding oxidases and nCuCe, were developed. These ABSs exhibited improved analytical characteristics in comparison with the appropriate bi-enzyme ABSs containing natural PO. Including electrodeposited porous gold in the chemo-sensing layer was shown to increase significantly the sensitivities of all constructed ABSs.
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