Abstract
A new curcumin-based biosensor (E)-5-(4-hydroxyphenyl)-1-phenylpent-4-ene-1,3‑dione (5HPD) was successfully synthesized for the selective detection of citrulline (Cit). Job's plot analysis indicated, a 1:1 binding stoichiometry between the sensor (5HPD) and citrulline. The binding constant was estimated to be 3.55 × 107 M−1 according to the Stern Volmer method. The newly synthesized sensor 5HPD is highly selective detection towards citrulline with various competitive biomolecules. Linearity ranges of 10 - 60 μM and lower detection limits is 75 nM. Interestingly, a reversible process provoke successively by 5HPD, Cit with EDTA observed and molecular logic circuits. The Mechanism of sensing 5HPD-Cit has been characterized clearly by 1H NMR, FTIR, ESI-MS spectroscopy and DFT calculation.
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