Abstract
The antibiotic resistance has become a worldwide threat to public health, and has been conventionally recognized for extensive usage of antibiotic in medicinal and agricultural applications. In this study new thiazole acetate incorporating triazole 6 was successfully synthesized using click reaction and characterized through UV–Visible, FT-IR, Mass and NMR spectroscopic techniques. The supramolecular interaction of compound 6 towards commonly used drugs has been investigated using fluorescence spectroscopy. The supramolecule 6 displayed distinctive quenching in the fluorescence intensity after mixing with Pefloxacin, selectively in the presence of other drugs at pH 6, with a linear range of concentration from 1 to 11 μM (R2 = 0.9889) and a limit of detection down to 0.24 μM. The binding stoichiometry between 6 and Pefloxacin was found to be 1:2 (6: Pefloxacin) as revealed by Job's plot method. Compound 6 is highly selective for Pefloxacin even in the presence of other widely used medicinal drugs, as no interference was observed in competitive experiments. More over compound 6 was successfully used for the detection of Pefloxacin in tap water and human plasma samples.
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