Abstract
Glucose concentration is an important physiological index, therefore methods for sensitive detection of glucose are important. In this study, Au foam was prepared by electrodeposition with a dynamic gas template on an Au nanoparticle/Si substrate. The Au foam showed ultrasensitivity, high selectivity, and long-term stability in the quantitative detection of glucose. The foam was used as an electrode, and the amperometric response indicated excellent catalytic activity in glucose oxidation, with a linear response across the concentration range 0.5 μM to 12 mM, and a limit of detection of 0.14 μM. High selectivity for interfering molecules at six times the normal level and long-term stability for 30 days were obtained. The results for electrochemical detection with Au foam of glucose in human serum were consistent with those obtained with a sensor based on surface-enhanced Raman spectroscopy and a commercial sensor. This proves that this method can be used with real samples. These results show that Au foam has great potential for use as a non-enzymatic glucose sensor.
Highlights
Diabetes is a metabolic disease, the main symptom of which is hyperglycemia
The diffraction peaks from Si were not present, which indicated that Au was well deposited on the Au/Si substrate
Highly porous Au foam was obtained by electrochemical deposition with an artful hydrogen and ammonia bubble dynamic template
Summary
Diabetes is a metabolic disease, the main symptom of which is hyperglycemia. Diabetes is mainly diagnosed by determining the concentration of glucose in blood or urine. The monitoring of glucose in human blood helps diabetics to understand their condition and reduce the incidence of diabetic complications [2,3]. There has been a growing demand for glucose monitoring in the fermentation [4], food [5] and chemical industries [6] during the past few decades. The development of sensors for fast, sensitive, accurate, and reproducible glucose determination is needed. Many strategies for glucose detection have been developed, including optical [7], fluorescence [8], electrochemical [9], and chromatographic techniques [10]
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