Highly regioselective ring-opening of aziridines with arenesulfinates on water: a facile access to β-amino/vinyl sulfones

Abstract

We have developed a LiBr catalyzed efficient synthesis of β-amino sulfones from readily available aziridines and sodium sulfinates in good to excellent yields. The synthetic potential of β-amino sulfones has also been demonstrated by their facile conversion to the corresponding vinyl sulfones. The use of water as reaction media, atom-economy and isolation of products by simple filtration in the case of solid β-amino sulfones are certain green virtues of the synthetic protocol.