Year-end Sale % OFF 
Abstract
A simple and cost‐efficient nickel catalytic system for the annulation of 2‐haloaldimines with alkynes to synthesize 3,4‐disubstituted and 3‐substituted isoquinolines at room temperature has been developed. The air‐stable and inexpensive Ni(dppe)Cl2 was employed as a precatalyst, and Et3N was found to be an essential additive for obtaining high yields. By using this nickel catalytic system one‐pot three‐component direct synthesis of isoquinolines starting with simple 2‐halobenzaldehydes, tert‐butylamine, and alkynes were also achieved. These reactions occur in moderate to excellent yields with complete regioselectivity. Moreover, these reactions feature a broad substrate scope, easy scalability, operational simplicity, and excellent practicality.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
