Abstract
The rapid advance in swept-source optical coherence tomography (SS-OCT) technology has enabled exciting new applications in elastography, angiography, and vibrometry, where both high temporal resolution and phase stability are highly sought-after. In this paper, we present a 200 kHz SS-OCT system centered at 1321 nm by using an electro-optically tuned swept source. The proposed system's performance was fully characterized, and it possesses superior phase stability (0.0012% scanning variability and <1 ns timing jitter) that is promising for many phase-sensitive imaging applications. Biological experiments were demonstrated within ex vivo human tracheobronchial ciliated epithelium where both the ciliary motion and ciliary beat frequency were successfully extracted.
Highlights
Optical coherence tomography (OCT) is an optical imaging modality developed on the basis of low coherence interferometry [1]
We present a 200 kHz phase-resolved swept-source optical coherence tomography (SS-OCT) system centered at 1321 nm with high phase stability
Phase stability To assess the theoretical phase performance of the system, we have conducted a series of measurements based on the noise theory we recently developed for SS-OCT systems [18]
Summary
Optical coherence tomography (OCT) is an optical imaging modality developed on the basis of low coherence interferometry [1]. SS-OCT has demonstrated clinical utility in a variety of medical applications including ophthalmology [3], cardiology [4, 5], pulmonology [6], gastroenterology [7, 8], and oncology [9] through various clinical trials. The structural information provided by OCT is sometimes insufficient for a comprehensive understanding of biological samples, and extra functional contrast capabilities such as phase contrast are often sought. In OCT angiography (OCTA), the phase change between consecutive A-lines could be used to obtain the Doppler frequency shift resulted from the blood flow, and the blood flow rate [10, 11]. In optical coherence elastography (OCE), the phase change of the sample induced by external mechanical stimulus is recorded and analyzed to obtain its mechanical properties [12,13,14]. In polarization-sensitive OCT (PS-OCT), the relative phase difference between the orthogonal polarization channels is utilized to reconstruct the polarization properties of the sample [15,16,17]
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