Abstract
We isolated highly pathogenic avian influenza virus (H5N8) of clade 2.3.4.4 from the common coot (Fulica atra) in Egypt, documenting its introduction into Africa through migratory birds. This virus has a close genetic relationship with subtype H5N8 viruses circulating in Europe. Enhanced surveillance to detect newly emerging viruses is warranted.
Highlights
A novel reassortant virus of subtype H5N8 clade 2.3.4.4 was reported in Russia and further spread to many countries in Europe, Asia, and the Middle East (4,5)
Lake Manzala in northern Egypt is a source of fish and a major refuge for many migratory birds
We observed 3 amino acid assignment differences in the HA protein, namely, R22K, E268G, and D487Y, which distinguished EG-CA285 from the recent highly pathogenic avian influenza virus (HPAIV) (H5N8) clade 2.3.4.4b strain isolated in Russia (A/ great-crested-grebe/Uvs-Nuur-Lake/341/2016; GISAID accession no EPI_ISL_224580) (Figure, panel A)
Summary
Pathogenic Avian Influenza Virus (H5N8) Clade 2.3.4.4 Infection in Migratory Birds, Egypt Author affiliations: National Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Giza, Egypt We isolated highly pathogenic avian influenza virus (H5N8) of clade 2.3.4.4 from the common coot (Fulica atra) in Egypt, documenting its introduction into Africa through migratory birds.
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