Abstract
An outbreak of low-pathogenicity avian influenza A(H7N3) virus of North American wild bird lineage occurred on commercial turkey farms in North Carolina and South Carolina, USA, during March–April 2020. The virus mutated to the highly pathogenic form in 1 house on 1 farm via recombination with host 28S rRNA.
Highlights
An outbreak of low-pathogenicity avian influenza A(H7N3) virus of North American wild bird lineage occurred on commercial turkey farms in North Carolina and South Carolina, USA, during March–April 2020
All the premises affected by lowpathogenicity avian influenza viruses (LPAIVs) and Highly pathogenic avian influenza viruses (HPAIVs) H7N3 were located in 3 adjacent counties and 1 across state lines, indicating that geographic proximity was relevant to the outbreaks
The 27-nt insertion coding for 9 amino acids at the HA cleavage site (PENPKTDRKSRHRRIR/ GLF; insertion sequence is underscored) is identical to that found in a 2017 HPAIV H7N9 from a poultry outbreak that occurred in Tennessee [2]
Summary
An outbreak of low-pathogenicity avian influenza A(H7N3) virus of North American wild bird lineage occurred on commercial turkey farms in North Carolina and South Carolina, USA, during March–April 2020. H5 and H7 lowpathogenicity avian influenza viruses (LPAIVs) have spontaneously mutated into HPAIVs by different mechanisms, one of which is acquisition of basic amino acids at the hemagglutinin (HA) cleavage site [1].
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