Abstract
To meet the ever increasing demand for higher throughput in ion channel screening and safety testing, new platforms are being introduced allowing for yet more throughput whilst retaining data quality. A new platform recording from 96 cells at a time with giga-seals, with continuous recording during compound application and addition of multiple compounds to each of the 96 cells being recorded will be described. This new platform vastly increases throughput, while reducing the cost per data point. Borosilicate glass substrates containing microstructured apertures are used for parallel patch clamp experiments. In the figure below, a screenshot of an experiment on 96 cells in a parallel is displayed. Shown are raw current responses of CaV3.2 channels expressed in HEK293 cells to a current voltage relationship step protocol.Recordings from various ligand- and voltage-gated ion channels on this platform will be shown.View Large Image | View Hi-Res Image | Download PowerPoint Slide
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