Abstract
AbstractNovel 9‐α‐hydroxy‐11‐keto‐β‐boswellic acid analogues constituted with versatile functionality at ring A have been synthesized for the first time from 3‐O‐acetyl‐11‐keto β‐boswellic acid (AKBBA) and described herein. The anti‐malarial potential of endoperoxide benzyl ester was evaluated against the malarial parasite and exhibited reasonable anti‐malarial activity (2 μM). Anti‐inflammatory potential of all new analogues was examined against proinflammatory cytokine, Tumor Necrosis Factor‐alpha (TNF‐α) and one of them was found to possess similar activity as that of AKBBA.
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