Abstract
The method was developed for the synthesis of biologically important adenosine phosphates, AMP, cAMP and ATP modified with p-carborane cluster - a highly lipophilic pharmacophore. The adenosine phosphates modified with p-carborane are characterized by increased stability in human blood plasma and much more higher lipophilicity than that of the unmodified phosphates. ATP analog 4 bearing p-carborane cluster is not a Taq polymerase substrate and most probably not the polymerase inhibitor. These properties may have clinical implications.
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