Abstract
Antibiotics with multi-photon absorption are expected to play an important role in biomedicine. A novel mononuclear organotin complex RJSnBu3 is designed, synthesized and systematically studied in this work. It is found that RJSnBu3 has a suitable three-photon active cross section under 1400 nm excitation (NIR II region). RJSnBu3 can inhibit the growth of Galanz-positive bacteria (Bacillus subtilis) and Galanz-negative bacteria (Escherichia coli) in the antibacterial screening. Compared to kanamycin, RJSnBu3 has excellent inhibitory effect on Bacillus subtilis. Importantly, the results of in vitro nucleic acid titration and two-photon bacterial imaging shows that RJSnBu3 can damage the bacteria cell membrane. The cytosol flows out when RJSnBu3 binds to DNA, causing the bacteria to die. The multi-photon in vivo imaging results reveal that RJSnBu3 could be ultra-sensitive for detection of colitis mice. These results provide that RJSnBu3 has promising applications for multiphoton imaging and the development of specific antibacterial drugs.
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