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Abstract
As the CA1 sector has been implicated to play a key role in memory formation, a dedicated search for highly expressed genes within this region was made from an on-line atlas of gene expression within the mouse brain (GENSAT). From a data base of 1013 genes, 16 were identified that had selective localization of gene expression within the CA1 region, and included Angpt2, ARHGEF6, CCK, Cntnap1, DRD3, EMP1, Epha2, Itm2b, Lrrtm2, Mdk, PNMT, Ppm1e, Ppp2r2d, RASGRP1, Slitrk5, and Sstr4. Of the 16 identified, the most selective and intense localization for both adult and post-natal day 7 was noted for ARHGEF6, which is known to be linked to non-syndromic mental retardation, and has also been localized to dendritic spines. Further research on the role played by ARHGEF6 in memory formation is strongly advocated
Highlights
As the CA1 sector has been implicated to play a key role in memory formation, a dedicated search for highly expressed genes within inhibition of CA1 and found that long-term memory retrieval normally depends on the hippocampus but can adaptively shift to alternate structures [...] we confirm the remote
High activity was selectively localized to CA1 for the following 16 genes: Angpt[2], ARHGEF6, CCK, Cntnap[1], DRD3, epithelial membrane protein 1 (EMP1), Epha[2], Itm2b, Lrrtm[2], midkine gene (Mdk), PNMT, Ppm1e, Ppp2r2d, RASGRP1, Slitrk[5], and Sstr[4] (Figure 1)
That CA1 is critical to new memory formation, a gensat.org/HistologyProtocol.pdf
Summary
As the CA1 sector has been implicated to play a key role in memory formation, a dedicated search for highly expressed genes within inhibition of CA1 and found that long-term memory retrieval normally depends on the hippocampus but can adaptively shift to alternate structures [...] we confirm the remote-. From a data base of 1013 genes, 16 ly were identified that had selective localization of gene expression within the CA1 region, and n included Angpt[2], ARHGEF6, CCK, Cntnap[1], o DRD3, EMP1, Epha[2], Itm2b, Lrrtm[2], Mdk, PNMT, Ppm1e, Ppp2r2d, RASGRP1, Slitrk[5], and e Sstr[4].
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