Highly exfoliated functionalized MoS2 with sodium alginate-polydopamine conjugates for electrochemical sensing of cardio-selective β-blocker by voltammetric methods.

Abstract

Molybdenum disulfide (MoS2) surface functionalization was performed with a catechol-containing polymer sodium alginate (SA) and dopamine (DA) through simultaneous MoS2 exfoliation and self-polymerization of DA. TheMoS2/SA-PDA nanocomposite was characterized usingspectroscopic, microscopic, and electroanalytical techniques to evaluate its electrocatalytic performance. The electrocatalytic behavior of the MoS2/SA-PDA nanocomposite modified electrode for the detection of acebutolol (ACE), a cardio-selective β-blocker drug was explored through cyclic voltammetric and differential pulse voltammetric techniques. The influence of scan rate, concentration, and pH value on the oxidation peak current of ACE was investigated to optimize the deducting condition. The electrochemical activity of theMoS2/SA-PDA nanocomposite electrode was attributed to the existence of reactive functional groups beingcontributed from SA, PDA, and MoS2 exhibiting asynergic effect. The MoS2/SA-PDA nanocomposite modified electrode exhibits admirable electrocatalytic activity with awidelinear response range (0.009 to 520μM), low detection limit (5nM), and highsensitivity (0.354μAμM-1cm-2)also in the presence of similar (potentiallyinterfering) compounds. Thefabricated MoS2/SA-PDA nanocomposite modified electrode can be useful for the detection of ACE in pharmaceutical analysis.