Abstract

Highly enantioselective Michael reaction of acetone with a variety of nitroolefins catalyzed by N-[(1R,2R)-2-aminocyclohexyl]-N′-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)-thiourea (1b) together with acetic acid is described. The Michael addition products were obtained in high yields (76–94%) and up to 96% ee.

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