Abstract
AbstractA highly efficient Friedel–Crafts reaction of 4,7‐dihydroindoles with β,γ‐unsaturated α‐keto esters by a chiral N‐triflyl phosphoramide was realized, affording the 2‐substituted 4,7‐dihydroindoles with up to 98% ee for a wide range of substrates. The Friedel–Crafts alkylation together with a subsequent oxidation of the product with p‐benzoquinone led to a 2‐alkylated indole derivative in 98% ee.
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